The AGORA Pôle de recherche sur le cancer, located in Lausanne within sight of Lake Geneva, specifically provides working and research space for 400 scientists and practitioners under one roof. The major focus was on a comprehensive, holistic concept to design communication and working spaces for the cancer research center. Existing visual connections on the site and to the landscape beyond were crucial for a cautious formulation and adaption of the building mass. Thus, the building’s sculptural character makes it easily recognizable within its surroundings and contributes to its autonomous presence. Connecting the most diverse requirements into an extremely heterogeneous and tight urban fabric places great demands on the architectural and programmatic concept. The decision to link to an existing building on the one side while creating a harmonious transition to nature on the other, informs the building’s structure without adversely affecting the site’s existing programmatic functions. Spatial qualities, directly perceived through daylight, proportion, and materiality, are equally visible in public areas and in the highly technical laboratories. The building skin is designed to enhance daylight use in the depth of the building. This provides for a better individual climate control. Daylight enhancement systems, optimized sunlight protection, the responsible management of natural resources in the construction and maintenance of the building, as well as the use of both renewable and existing energy systems on site are preconditions for a successful and sustainable working environment. They, together with ISREC’s own research goals, establish a future oriented image for the new facility.